|
Proton Spectroscopy Prostate Cancer
June 19, 2001
Courtesy: Gasthuisberg University Hospital, Belgium
System: Intera 1.5T with 1H spectroscopy package (no special hardware/software used)
Multi-Voxel Spectroscopy & Spectroscopic Imaging
Back to top
BodyTop right: anatomical image
Positions of spectroscopy voxels 1-10 are overlaid. Note also the excellent image quality obtained with the Philips endo-cavitary coil.
Center: Spectra 1-10 from voxels 1-10.
Scan time: 20 minutes.
Voxel size: 8x8x10 mm (0.64 cc).
Note excellent separation between the choline and creatine peaks (eg. spectra 1-5). Spectrum 7 also shows resolution of the citrate doublet (two peaks). (See next image for identification of peaks)
Bottom right: citrate metabolite image.
Level of brightness indicates citrate intensity.
Overlaid red lines are the contours of the anatomical image.
All images and spectra were acquired with Philips' endo-cavitary coil.
Next image compares two particular spectra, 3 & 5.
Expanded spectra from voxels 3 & 5
Spectrum 3 - more normal tissue
a) Note the choline/citrate ratio, with relatively large citrate peak. (This corresponds with bright area surrounding voxel 3 in the citrate image).
b) Choline/creatine ratio: similar peak intensities
Spectrum 5 - tumor
a)Choline/citrate ratio is dramatically changed. This ratio is known to be an important indicator of tumor. The citrate peak is greatly reduced. (Corresponds with dark area surrounding voxel 5 in citrate image).
b) choline/creatine ratio : choline peak is substantially higher than creatine.
Tumor was confirmed by biopsy.
Protocol:
Intera 1.5T with:
- 1H spectroscopy package
- Endo cavitary coil
|
2D spectroscopic imaging:
- Single slice
- Voxel size 8x8x10 mm = 0.64 cc
|
Note : Water suppression was achieved simply with the WS-TE pulse. Water suppression parameter was set to No.
Summary
- All results from commercial Intera 1.5T
- Results demands high-quality MR system design
- Demonstrates Intera high-quality spectroscopy, integrated with imaging, in hospital environment
- Further clinical evaluation in Leuven, Belgium
- Feeds into Intera Spectroscopy program
|
Prostate cancer
Anatomical Images
The following are further anatomical images obtained with Philips' endo-cavitary coil, with excellent image quality.
Note the high resolution of these thin-slice T2 TSE images.
The T2 TSE protocol is essential for prostate imaging. Tumors are observed as hypointense homogenous regions typically lying within the brighter peripheral zone.
Benign prostatic hyperplasia is demonstrated within the central gland.
Hypointense signal in both superior aspects of peripheral zone is highly suggestive of tumour.
| |
 |  | Transverse T2W TSE
160 mm FOV, 0.56 mm * 0.69 mm
2.5 mm slice, Scan time: 5:30 mins | Coronal T2W TSE
140 mm FOV, 0.54 mm * 0.74 mm
3.0 mm slice, Scan time: 3:08 mins |
|
| |
|
|
